After Joseph Brody is critically injured during the Male M.U.T.O.'s escape from Janjira, he and Ford are airlifted to the Saratoga with Vivienne Graham and Ishiro Serizawa aboard a Monarch helicopter. Unfortunately, Joseph dies before the helicopter reaches the aircraft carrier. Once onboard, Ford learns more about the monster which killed his father, and of Ishiro's knowledge of another mysterious monster. After a day or so, Ford departs for Honolulu aboard another Monarch helicopter, as part of a journey to return to San Francisco. Shortly afterwards, a squadron of U.S.A.F.planes and helicopters lift off from the Saratoga, bound for Hawaii, after they learned of a Russian submarine that was under attack off the coast of Oahu. Afterwards, the Aircraft Carrier follows Godzilla to San Francisco, but stays out at sea to avoid being struck by the M.U.T.O.s' Electromagnetic Pulses.
Early concept art for Godzilla suggests that Godzilla would attack an aircraft carrier during an early version of the film's plot.
Multiple ships owned by the US Navy have bore the name Saratoga, with the most recent aircraft carrier bearing the name to have the code CVN-60.