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Some time before the events of the film, a ship came ashore on the island. Its crew disappeared, leaving the ship to get covered in mold. Later, another ship full of several young men and women ran aground on Matango Island in the midst of a storm, disabling their boat. Exploring the island, they found what looked like a paradise - a lush jungle adorned Matango Island, full of pools containing clean water and an abundance of strange-looking mushrooms. At first, the survivors refrained from consuming the fungi, afraid of what it would do to them. Eventually, one survivor grew desperate, and ate one of the mushrooms. What followed was to bring terror to the peaceful island. Gradually, the man began to mutate and grow fungus all over their body, eventually transforming completely into Matango. Over time, more and more of the survivors became infected, until one survivor managed to escape on the moldy boat. However, upon his return to Japan, he too begun to slowly be colonized, ending his sanity by remarking on how similar humans and Matango were to each other.