The Giant Gila Monster was found in an unknown location by Tobias Wilson, owner of a mutant circus, the Giant Gila Monster was captured and put on a display. Using the excuse he was teaching the public about the creatures, he had his crew train his pets. The Giant Gila Monster, along with other mutants, were forced to do tricks and perform until Medusa, a water-absorbing mutant sea anemone, escaped and created all sorts of havoc. With Tobias Wilson captured, the circus was shut down and whatever happened to his captive creatures remains a mystery.
- The Giant Gila Monster is the titular antagonist of the 1959 classic film The Giant Gila Monster (1959).
- Giant Gila Monster is the only American monster.