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The Giant Anaconda lived in the Amazon, but was driven north due to deforestation. While swimming in a river, the Giant Anaconda came across a little girl, whom she tried to eat. The Giant Anaconda was soon attacked by King Kong, who was in turn attacked by Bionobots, which the two fight together. During the fight, Kong becomes distracted and the Giant Anaconda is flown away in the claws of a pterodactyl Bionobot. In the laboratory of Dr. Richard Remy, the Giant Anaconda is outfitted with Bionobot armor that puts her under the control of Dr. Remy. She then fights Kong on Alcatraz island by constricting him and electrocuting him. Kong is able to subdue the creature by having it swallow a battery to overcharge her. When it is out of Remy's hands, Lucas Remy and Doug Jones then return the Giant Anaconda to the wild.
With its Bionobot armor, the Giant Anaconda can send an electric shock through its body and into its prey.
- Main article: Giant Anaconda/Gallery.